TECENTRIQ® (atezolizumab) injection
IMPORTANT FACTS ABOUT TECENTRIQ
The information provided here is not
comprehensive. To learn more, talk to your
healthcare provider (HCP).
Call 1 (844) TECENTRIQ (832-3687)
or go to TECENTRIQ.com to get FDA-approved
product labeling, including Medication Guide.
What is the most important information
I should know about TECENTRIQ?
• TECENTRIQ is a medicine that may treat your bladder
cancer by working with your immune system.
TECENTRIQ can cause your immune system to
attack normal organs and tissues in many areas of
your body and can affect the way they work. These
problems can sometimes become serious or life
threatening and can lead to death.
Call or see your HCP right away if you get any
symptoms of the following problems or these
symptoms get worse:
• Lung problems (pneumonitis). Signs and
symptoms may include: new or worsening cough,
shortness of breath, chest pain.
• Liver problems (hepatitis). Signs and symptoms
may include: yellowing of your skin or the whites
of your eyes, severe nausea or vomiting, pain on
the right side of your stomach area (abdomen),
drowsiness, dark urine (tea colored), bleeding or
bruising more easily than normal, feeling less
hungry than usual.
• Intestinal problems (colitis). Signs and symptoms
may include: diarrhea (loose stools) or more bowel
movements than usual, blood in your stools or dark,
tarry, sticky stools, severe stomach area (abdomen)
pain or tenderness.
• Hormone gland problems (especially the
pituitary, thyroid, adrenal glands, and pancreas).
Signs and symptoms may include: headaches that
will not go away or unusual headaches, extreme
tiredness, weight gain or weight loss, dizziness or
fainting, feeling more hungry or thirsty than usual,
hair loss, changes in mood or behavior (such as
decreased sex drive, irritability, or forgetfulness),
feeling cold, constipation, your voice gets deeper,
urinating more often than usual, nausea or vomiting,
stomach area (abdomen) pain.
• Nervous system problems (neuropathy,
meningitis, encephalitis). Signs and symptoms
may include: severe muscle weakness, numbness or
tingling in hands or feet, fever, confusion, changes in
mood or behavior, extreme sensitivity to light, neck
• Inflammation of the eyes. Signs and symptoms
may include: blurry vision, double vision, or other
vision problems, eye pain or redness.
• Severe infections. Signs and symptoms may
include: fever, cough, frequent urination, flu-like
symptoms, pain when urinating.
• Severe infusion reactions. Signs and symptoms
may include: chills or shaking, itching or rash,
flushing, shortness of breath or wheezing, dizziness,
fever, feeling like passing out, back or neck pain,
swelling of your face or lips.
Getting medical treatment right away may
help keep these problems from becoming
Your HCP will check you for these problems during
your treatment with TECENTRIQ. Your HCP may treat
you with corticosteroid or hormone replacement
medicines. Your HCP may delay or completely stop
treatment with TECENTRIQ if you have severe side
What is TECENTRIQ?
TECENTRIQ is a prescription medicine used to treat:
a type of bladder and urinary tract cancer called
• TECENTRIQ may be used when your bladder
— has spread or cannot be removed by surgery
(advanced urothelial carcinoma), and
— you are not able to take chemotherapy that
contains a medicine called cisplatin, or
— you have tried chemotherapy that contains
platinum, and it did not work or is no longer
It is not known if TECENTRIQ is safe and effective in
children. The approval of TECENTRIQ in these patients
is based on a study that measured response rate and
duration of response. There is an ongoing study to
confirm clinical benefit.
What should I tell my HCP before
Before you receive TECENTRIQ, tell your HCP about
all of your medical conditions, including if you:
• have immune system problems such as Crohn’s
disease, ulcerative colitis, or lupus
• have had an organ transplant
• have lung or breathing problems
• have liver problems
• have a condition that affects your nervous
system, such as myasthenia gravis or
• are being treated for an infection
• are pregnant or plan to become pregnant.
TECEN TRIQ can harm your unborn baby. If you
are able to become pregnant, you should use an
effective method of birth control during your
treatment and for at least 5 months after the last
dose of TECENTRIQ.
• are breastfeeding or plan to breastfeed. It is not
known if TECEN TRIQ passes into your breast milk. Do
not breastfeed during treatment and for at least 5
months after the last dose of TECENTRIQ.
Tell your HCP about all the medicines you take,
including prescription and over-the-counter medicines,
vitamins, and herbal supplements.
How will I receive TECENTRIQ?
• Your HCP will give you TECENTRIQ into your vein
through an intravenous (IV) line over
30 to 60 minutes.
• TECENTRIQ is usually given every 3 weeks.
• Your HCP will decide how many treatments
• Your HCP will test your blood to check you
for certain side effects.
• If you miss any appointments, call your
HCP as soon as possible to reschedule
What are the possible side effects of
TECENTRIQ can cause serious side effects,
• See “What is the most important information I
should know about TECENTRIQ?”
The most common side effects of TECENTRIQ in
people with urothelial carcinoma include: feeling
tired, decreased appetite, nausea, constipation, urinary
tract infection, diarrhea, fever.
TECENTRIQ may cause fertility problems in females,
which may affect the ability to have children. Talk to
your HCP if you have concerns about fertility.
These are not all the possible side effects of
TECENTRIQ. Ask your HCP or pharmacist for more
information. Call your doctor for medical advice about
side effects. You may report side effects to the FDA at
TECEN TRIQ is a registered trademark of Genentech, Inc.
U. S. License No. 1048 Issued: April 2017
© 2017 Genentech USA, Inc. All rights reserved.
A path forward