New Tool to Calculate Breast Cancer Risk in
Women in Nigeria
Using data from the Nigerian Breast Cancer
Study, researchers developed the first breast
cancer risk prediction model for women in sub-Saharan Africa. These women have different
risk factors and lower incidence rates of
breast cancer than white or black women in
the U.S. and do not currently receive routine
breast cancer screening. The new tool can be
used to identify the high-risk women most
likely to benefit from screening.
LEARN MORE IN THE JUNE 2018 CANCER
EPIDEMIOLOGY, BIOMARKERS & PREVENTION.
FREDERICK F. LANG ON VIRUS-POWERED
From Cold Virus
to Cancer Fighter
Anyone who has experienced the sneezing, runny nose and scratchy throat that accompany a cold knows the power of a tiny virus. The discomfort
begins when the virus gets into the cells in your nose or
throat, triggering an immune response—an army of white
blood cells and a lot of mucus.
But what if that virus’s ability to get into a cell could be used to treat
disease? Scientists have been conducting research seeking to answer
that question for decades. Now, new technologies have made it possible
to hijack a virus and use it to kill cancer cells.
Frederick F. Lang, a neurosurgeon at the University of Texas M.D.
Anderson Cancer Center in Houston, is part of a research team studying
the effectiveness of a common cold virus that has been transformed into
a possible treatment for recurrent glioblastoma, an aggressive type of
brain cancer. Cancer Today spoke with Lang about his research and the
use of viruses to treat cancer.
Q: How does a cold virus kill cancer cells?
A: Viruses enter and replicate in cells really well, and the signaling
pathways in tumors are very susceptible to virus infection and replication.
Just like a virus can enter a normal cell, a virus can get inside a tumor
cell. Before we developed genetic engineering, there was no way to control
how the virus acted in normal cells. Now we can engineer the virus so it
will kill cancer cells and not normal cells.